Order Doxycycline - Description and Clinical Pharmacology
Doxycycline - why I need to buy and use these pills? Instructions for use, reviews
Doxycycline - from what to buy these pills? Surely, many patients who were prescribed this medication, worried about this issue.
After all, very often doctors recommend buying and taking those or other drugs, without explaining why they are needed, how they affect the body, whether they have contraindications and side effects. As a result, the condition of some patients may not improve, but, on the contrary, worsen.
In connection with all of the above, before taking any medication, we recommend that you clarify with the doctor why he was appointed to you. If you did not receive an intelligible answer, we advise you to carefully study the attached instructions.
So, Doxycycline. What are these pills and whether they have contraindications? These and other questions regarding this drug we will answer in the article presented.
Composition, form, description and packaging of the drug
Before answering the question: Doxycycline - what are these tablets from? , It is necessary to tell what composition this medication has.
The composition of the drug under consideration includes such an active element as doxycycline (this substance in the instructions is presented in the form of doxycycline hiclate).
In addition, the drug contains the following additional ingredients: magnesium stearate, lactose monohydrate and potato starch. The drug "Doxycycline" goes on sale in the form of hard capsules made of gelatin, which have the shape of a cylinder and yellow color. Inside of them there is a yellowish powder with white impregnations.
Very often the form of the drug is called a tablet. Although in fact they are not.
The capsule shell of this agent consists of propyl parahydroxybenzoate, glycerol, methyl parahydroxybenzoate, gelatin, E110 and E104 additives, and sodium lauryl sulfate.
In what packaging is Doxycycline sold?
The capsules are placed in the cellular contour packs, which are contained in cardboard boxes. One can not help saying that this medication is also manufactured in the form of a lyophilizate, which is used to prepare an infusion solution.
The principle of the antibiotic drug Doxycycline
What is the drug Doxycycline? The instruction (price, drug reviews are presented below) states that this is a semi-synthetic antibiotic agent belonging to a group of antibiotics - tetracyclines, which have a fairly wide range of action.
The drug under consideration is capable of producing bacteriostatic effects. It inhibits the processes of protein synthesis in harmful microorganisms. Penetrating into the cells, the active substance of the drug immediately affects the pathogens in them. Doxycycline hiclata inhibits the synthesis of proteins in microbial cells, and also disrupts the transport of aminoacyl-RNA.
Features of this medicinal product
With respect to which bacteria is the most effective drug Doxycycline?
The action (pernicious) of this drug is directed to such Gram-positive microorganisms, as aerobic cocci, aerobic and anaerobic spore-forming, as well as aerobic non-spore-forming bacteria.
Among other things, taking this medication negatively affects the life of such gram-negative microbes, as aerobic cocci and aerobic bacteria. What is the difference between the antibiotic Doxycycline and Tetracycline?
According to reviews of specialists, the last drug to a lesser degree depresses the intestinal microflora. In addition, its absorption is more complete, and the therapeutic effect is long-lasting.
It should also be noted that the antibacterial activity we are considering is much higher in antibacterial activity than in natural tetracyclines. The instruction asserts that the therapeutic efficacy of this drug is manifested when taking even small medicinal doses.
Kinetic parameters of capsules
Is the antibiotic Doxycycline absorbed?
Absorption in this medicine is very high and fairly fast (about 100%). In this case, eating does not affect the degree of absorption. The drug dissolves fairly easily in lipids. However, it has a low affinity for the binding of calcium ions.
After taking the medicine in an amount of 200 mg, the time to reach its highest concentration in the blood is 2.5 hours. The active substance of the antibiotic binds to plasma proteins by 80-95%. It penetrates quite well into tissues and organs.
Approximately 45 minutes after oral administration, therapeutic drug concentrations are found in the liver, spleen, kidneys, prostate, lungs, bones, eye tissues, teeth, bile, ascites and pleural fluids, synovial exudate, as well as in gingival fluid, exudate frontal and Maxillary sinuses.
It should also be noted that Doxycycline penetrates the spinal cord fluid rather poorly. Also, the agent in question is defined in breast milk and is found in the placenta. Metabolism of the antibiotic is carried out in the liver (about 30-55%).
Its half-life is 12-16 hours. With repeated use of the medicine, he can cumulate. The drug is excreted through the intestines and kidneys. In people with disrupted urinary system, excretion of the drug substance is carried out through gastrointestinal secretion.
The drug Doxycycline: for what diseases do you need to buy these pills?
There are a lot of indications for taking this medication. Tablets can be taken in the following cases:
- In otolaryngological practice with infections of the ENT organs (tonsillitis, otitis, sinusitis and others);
- Inflammatory and infectious diseases, which were caused by sensitive bacteria, as well as respiratory tract infections (tracheitis, pharyngitis, pneumonia, bronchitis, chronic or acute, lung abscess, lobar pneumonia, empyema);
- In gastroenterology in infections of the gastrointestinal tract and biliary tract (gastroenterocolitis, cholecystitis, diarrhea "travelers", bacillary dysentery, cholangitis);
- Soft tissue and skin infections (infected burns, phlegmon, abrasions, abscesses, wound, whitlow, etc...);
- Infectious diseases of the eye, yaws, syphilis, yersiniosis, rickettsiosis, legionella, chlamydia different localization, proctitis, prostatitis, Q fever, typhus (including tick, typhus and recurrent), the spotted fever, amoebic and bacillary dysentery, Lyme disease, actinomycosis, Tularemia, cholera, malaria;
- In Urology infections of the urogenital system (endometritis, cystitis, pyelonephritis, urethrocystitis, urethritis, endocervicitis, urogenital mycoplasmosis, acute orhiepididimit, prostatitis, gonorrhea);
- With exacerbation of chronic bronchitis to patients under 65 years of age as a medicine of the "first" series (without concomitant diseases);
- In bronchopulmonary infection (exacerbation) of staphylococcal origin in people with chlamydial arthritis, cystic fibrosis and granulocytic ehrlichiosis;
- With acute prostatitis and urinary infection in the elderly (caused by Escherichia coli);
- In combination therapy with leptospirosis, ornithosis, trachoma, psittacosis, granulocyte erlichiosis;
- In combined therapy with brucellosis, whooping cough, osteomyelitis, subacute septic endocarditis, sepsis, peritonitis;
- For prophylaxis of suppurative postoperative complications, when traveling on the territory where strains that are resistant to chloroquine, as well as malaria are especially common.
The way antibiotics are used for adults and children
How should I take the medicine Doxycycline (the price of the tablet is listed below)?
Antibiotic in capsules should be used after a meal. In this case, the drug should be washed down with a sufficient amount of warm liquid. The described administration of the drug significantly reduces the likelihood of irritations on the esophageal mucosa. The dosage recommended by the doctor, which the patient must take, must be divided into 2 divided doses. Use the capsule preferably once every 12 hours.
The drug Doxycycline: dosage
Typically, doctors prescribe this drug in the following dosage: on the first day - 200 mg, and then on 100-200 mg (depends on the course of the disease). If a patient has a severe infectious process, then throughout the therapy he is recommended to drink 200 mg of medication a day.
In pathological conditions that were caused by chlamydia, mycoplasma or ureaplasma, the antibiotic is given in a standard dosage. Take this drug is desirable for 11-15 days.
Can I combine Doxycycline with other tablets?
The compatibility of this with medication with other drugs is quite real. As a rule, it depends on the type of disease and its current. If required, the antibiotic in question can be combined with "Clindamycin" and "Gentamicin".
Other ways of taking an antibiotic
Capsules "Doxycycline" with a tick bite should be taken only on the advice of a doctor. It is very important to use the medicine for preventive purposes no later than 72 hours after a direct bite. In acute inflammatory diseases in women, the drug is prescribed in the amount of 100 mg twice a day.
Men are recommended to take it either in the same dosage and at the same frequency, or at a dose equal to 300 mg once. To children after reaching the age of 8, the drug is prescribed in an amount of 4 mg per kg on the first day, and then 2-4 mg per 1 kg per day (depending on the course of the disease).
To prevent infectious complications that may occur during an abortion, use 100 mg of the drug 60 minutes before the procedure and 200 mg after half an hour after. People with secondary and primary syphilis should take 300 mg of funds per day for 10 days.
The dose of Doxycycline in patients with gonorrhea should be 100 mg twice daily for 2-4 days. Men with gonorrheic urethritis are recommended a single dose of the drug in an amount of 300 mg. If the causative agent is stable, then you can take 200 mg of medication for 4 days (for women - for five days).
Antibiotic in the presence of acne and acne should be used at 50 mg per day. The duration of treatment should be 7-12 weeks. How to treat borreliosis? "Doxycycline" with this diagnosis is prescribed a course lasting 3-5 days in the amount of 200 mg a day.
Price and similar remedies. Buy Doxycycline online
How much is the drug "Doxycycline" price?
The price of a Doxycycline 100 mg:
- 30 pills - $36.06
- 90 pills - $51.53
- 360 pills - $121.16
If it is required to replace it, doctors recommend using the following antibiotic drugs: Doxycycline Ferein, Unidox Solutab, Dovycil, Doxycycline Hydrochloride, Doxylin, Doxycycline Nicomed, Doxepin, Doxycycline-AKOS.
It should immediately be noted that the cost of all of these funds can be much higher than the one under consideration. Therefore, in the absence of contraindications and side effects, patients prefer to use "Doxycycline".
You can buy doxycycline online by clicking on the official pharmacy.
Doxycycline Information Images